Biological and Medical Applications of Materials and Interfaces
- Yalong Li
Yalong Li
Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, P. R. China
Key Laboratory of Clay Minerals of Gansu Province, Research Center of Resource Chemistry and Energy Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
More by Yalong Li
- Fangfang Yang
Fangfang Yang
Key Laboratory of Clay Minerals of Gansu Province, Research Center of Resource Chemistry and Energy Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
More by Fangfang Yang
- Bin Mu
Bin Mu
Key Laboratory of Clay Minerals of Gansu Province, Research Center of Resource Chemistry and Energy Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
More by Bin Mu
- Yulong Ma
Yulong Ma
Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, P. R. China
More by Yulong Ma
- Aiqin Wang*
Aiqin Wang
Key Laboratory of Clay Minerals of Gansu Province, Research Center of Resource Chemistry and Energy Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
*Email: [emailprotected]. Tel.: +86 931 4968118; fax: +86 931 4968019.
More by Aiqin Wang
- Xinyue Liu*
Xinyue Liu
Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, P. R. China
*Email: [emailprotected]. Tel.: +86 931 5190360.
More by Xinyue Liu
Other Access OptionsSupporting Information (1)
ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
https://pubs.acs.org/doi/10.1021/acsami.5c00906
Published April 22, 2025
Publication History
Received
Accepted
Revised
Published
online
research-article
© 2025 American Chemical Society
Request reuse permissions
Abstract
Click to copy section linkSection link copied!
Silver nanoparticles (Ag NPs) have emerged as a promising solution to combat biofilm-related infections caused by multidrug-resistant bacteria. However, their practical application remains limited due to their tendency to aggregate and exhibit high toxicity at elevated concentrations. Here, we developed a Citrus limon peel water extract-mediated hydrothermal process to facilitate the heterogeneous nucleation of Ag NPs on attapulgite (APT) nanorods and prepared Ag/APT nanocomposites with ultrasmall Ag NPs (<2 nm) uniformly anchored on APT nanorods. Ascorbic acid and polyphenols in Citrus limon peel extract acted as electron donors to reduce Ag+ to Ag0, while the interfacial interaction of APT nanorods induced heterogeneous nucleation and confined the growth of Ag nanocrystals, resulting in ultrasmall Ag NPs. As a result, due to the synergistic effect of the targeted biofilm-binding affinity of APT nanorods and the siginificantly increased specific surface area of Ag NPs conducive to the release of Ag+ ions, the obtained Ag/APT nanocomposites exhibited enhanced eradication activities on antimicrobial-resistant bacterial biofilms and accelerated wound healing in MRSA-infected wound models. Additionally, attributing to the low dosage of Ag, Ag/APT exhibited exceptional biocompatibility both in vitro and in vivo. This work provides a simple and green strategy for the preparation of highly active Ag-based antibacterial nanomaterials and sheds new light on the development of advanced antimicrobial agents for wound healing.
ACS Publications
© 2025 American Chemical Society
Subjects
what are subjects
Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.
- Bacteria
- Biofilms
- Metal nanoparticles
- Nanocomposites
- Wound healing
Keywords
what are keywords
Article keywords are supplied by the authors and highlight key terms and topics of the paper.
Read this article
To access this article, please review the available access options below.
Get instant access
Purchase Access
Read this article for 48 hours. Check out below using your ACS ID or as a guest.
Recommended
Access through Your Institution
You may have access to this article through your institution.
Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.
Recommended
Log in to Access
You may have access to this article with your ACS ID if you have previously purchased it or have ACS member benefits. Log in below.
-
Purchase access
Purchase this article for 48 hours $48.00 Add to cart Purchase this article for 48 hours Checkout
Cited By
Click to copy section linkSection link copied!
This article has not yet been cited by other publications.
Download PDF
Get e-Alerts
Get e-Alerts
ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 22, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
Request reuse permissions
Article Views
36
Altmetric
-
Citations
-
Learn about these metrics
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.
